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https://er.knutd.edu.ua/handle/123456789/19275
Повний запис метаданих
Поле DC | Значення | Мова |
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dc.contributor.advisor | Palchevska, Tetiana | - |
dc.contributor.author | Yifan, Liu | - |
dc.date.accessioned | 2022-01-20T13:26:16Z | - |
dc.date.available | 2022-01-20T13:26:16Z | - |
dc.date.issued | 2021-12-20 | - |
dc.identifier.citation | Yifan Liu. Preparation and properties of oral adhesive plaster containing Periplaneta extract : master's thesis on the specialty 226 Pharmacy, Industrial Pharmacy / Yifan Liu ; supervisor T. Palchevska ; reviewer O. Baula. – Kyiv : KNUTD, 2021. – 101 p. | uk |
dc.identifier.uri | https://er.knutd.edu.ua/handle/123456789/19275 | - |
dc.description.abstract | This research is devoted to the development of a new type of oral adhesive tablet that combines polymer materials and natural biological extracts (Periplaneta americana). It has good adhesion, long adhesion time and high material quality. The medicine uses the natural extract of Periplaneta americana and uses its unique membrane repair effect. The material adopts high tensile strength, strong adhesion carbomer 941 and hydroxypropyl methyl cellulose polymer materials. MTT assay was used to determine the toxicity of drug-loaded adhesion layer matrix on Hela cells. The results show that ulcer patch had good biocompatibility. Finally, the drug release behavior from the ulcer patch was studied by an amino acids analysis in the release medium using amino acid analyzer. The results show that the active components of amino acids can be effectively released from the matrix of ulcer patch, which laid a foundation for the therapeutic effect.The slow-release effect of the film provides a more efficient way to treat oral ulcers. The key production process of the product in industrial production is introduced, and the corresponding suggestions are put forward. | uk |
dc.language.iso | en | uk |
dc.publisher | Kyiv National University of Technology and Design | uk |
dc.subject | oral ulcer patch | uk |
dc.subject | Periplaneta extract | uk |
dc.subject | bioadhesion | uk |
dc.subject | drug release | uk |
dc.title | Preparation and properties of oral adhesive plaster containing Periplaneta extract | uk |
dc.title.alternative | Приготування та властивості лейкопластиру для порожнини рота, що містить екстракт Periplaneta | uk |
dc.type | Дипломний проект | uk |
local.subject.faculty | Факультет хімічних та біофармацевтичних технологій | uk |
local.subject.department | Кафедра промислової фармації | uk |
local.subject.method | 1 | uk |
local.diplom.group | MPhch-20 | uk |
local.diplom.target | Тo develop a novel drug-loaded oral adhesive film that can adhere to the ulcer surface and play both a physical sealing role and continuously releasing drugs such as PAE. | uk |
local.diplom.object | Object of research is a new type of patch with Periplaneta extract, the recipe for which was developed at the Kyiv College of Qilu University of Technology, People's Republic of China. | uk |
local.diplom.predmet | The adhesive film for oral ulcer was designed as a double-layer structure: the inner adhesive layer was mainly prepared by carbomer and HPMC loaded extract of periplaneta that can slowly release to the ulcer surfac | uk |
local.diplom.method | A banburying method for high concentration carbomer solution was established, and a double-layer oral adhesive was prepared by layer upon layer casting method. To optimize the composition of the patch, various types of polyacrylic polymers were studied: carbomer 934, 940, 941 and polycarbophil, hydroxypropyl methylcellulose (HPMC) impregnated with PAE. To develop the technology of oral plaster and study its properties, the methods of internal mixing and tape casting were used in the work; methods of adhesiometry. MTT was used to determine the toxicity of drug-loaded adhesion layer matrix on Hela cells. The drug release behavior from the ulcer patch was studied by an amino acids analysis | uk |
local.diplom.okr | Магістр | uk |
local.diplom.speciality | 226 Pharmacy, industrial pharmacy | uk |
local.diplom.program | Industrial pharmacy | uk |
local.contributor.altadvisor | Пальчевська, Тетяна Андріївна | - |
Розташовується у зібраннях: | Кафедра промислової фармації (ПФ) Магістерський рівень |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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Diplom226_YifanLiu_Palchevska.pdf | 2,47 MB | Adobe PDF | Переглянути/Відкрити |
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