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Поле DCЗначенняМова
dc.contributor.advisorPalchevska, Tetiana-
dc.contributor.authorYifan, Liu-
dc.date.accessioned2022-01-20T13:26:16Z-
dc.date.available2022-01-20T13:26:16Z-
dc.date.issued2021-12-20-
dc.identifier.citationYifan Liu. Preparation and properties of oral adhesive plaster containing Periplaneta extract : master's thesis on the specialty 226 Pharmacy, Industrial Pharmacy / Yifan Liu ; supervisor T. Palchevska ; reviewer O. Baula. – Kyiv : KNUTD, 2021. – 101 p.uk
dc.identifier.urihttps://er.knutd.edu.ua/handle/123456789/19275-
dc.description.abstractThis research is devoted to the development of a new type of oral adhesive tablet that combines polymer materials and natural biological extracts (Periplaneta americana). It has good adhesion, long adhesion time and high material quality. The medicine uses the natural extract of Periplaneta americana and uses its unique membrane repair effect. The material adopts high tensile strength, strong adhesion carbomer 941 and hydroxypropyl methyl cellulose polymer materials. MTT assay was used to determine the toxicity of drug-loaded adhesion layer matrix on Hela cells. The results show that ulcer patch had good biocompatibility. Finally, the drug release behavior from the ulcer patch was studied by an amino acids analysis in the release medium using amino acid analyzer. The results show that the active components of amino acids can be effectively released from the matrix of ulcer patch, which laid a foundation for the therapeutic effect.The slow-release effect of the film provides a more efficient way to treat oral ulcers. The key production process of the product in industrial production is introduced, and the corresponding suggestions are put forward.uk
dc.language.isoenuk
dc.publisherKyiv National University of Technology and Designuk
dc.subjectoral ulcer patchuk
dc.subjectPeriplaneta extractuk
dc.subjectbioadhesionuk
dc.subjectdrug releaseuk
dc.titlePreparation and properties of oral adhesive plaster containing Periplaneta extractuk
dc.title.alternativeПриготування та властивості лейкопластиру для порожнини рота, що містить екстракт Periplanetauk
dc.typeДипломний проектuk
local.subject.facultyФакультет хімічних та біофармацевтичних технологійuk
local.subject.departmentКафедра промислової фармаціїuk
local.subject.method1uk
local.diplom.groupMPhch-20uk
local.diplom.targetТo develop a novel drug-loaded oral adhesive film that can adhere to the ulcer surface and play both a physical sealing role and continuously releasing drugs such as PAE.uk
local.diplom.objectObject of research is a new type of patch with Periplaneta extract, the recipe for which was developed at the Kyiv College of Qilu University of Technology, People's Republic of China.uk
local.diplom.predmetThe adhesive film for oral ulcer was designed as a double-layer structure: the inner adhesive layer was mainly prepared by carbomer and HPMC loaded extract of periplaneta that can slowly release to the ulcer surfacuk
local.diplom.methodA banburying method for high concentration carbomer solution was established, and a double-layer oral adhesive was prepared by layer upon layer casting method. To optimize the composition of the patch, various types of polyacrylic polymers were studied: carbomer 934, 940, 941 and polycarbophil, hydroxypropyl methylcellulose (HPMC) impregnated with PAE. To develop the technology of oral plaster and study its properties, the methods of internal mixing and tape casting were used in the work; methods of adhesiometry. MTT was used to determine the toxicity of drug-loaded adhesion layer matrix on Hela cells. The drug release behavior from the ulcer patch was studied by an amino acids analysisuk
local.diplom.okrМагістрuk
local.diplom.speciality226 Pharmacy, industrial pharmacyuk
local.diplom.programIndustrial pharmacyuk
local.contributor.altadvisorПальчевська, Тетяна Андріївна-
Розташовується у зібраннях:Кафедра промислової фармації (ПФ)
Магістерський рівень

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