The hesperidin inhibits the butyrylcholinesterase from serum of human

Abstract

Hesperidin shows a variety of pharmacological effects and is potentially promising for the treatment of neurodegenerative diseases. Literature review and in-house QSAR analysis showed that hesperidin also displays the various biological and pharmacological properties, including antiinflammatory, antineoplastic, antidepressant and antioxidant activity. Molecular docking of hesperidin into the active site of BChE allows to assume the existence of the inhibition effect. Hesperidin inhibits the BChE by mixed mechanism. Further comprehensive research in this area is relevant with aim of further development of drugs for the treatment of neurodegenerative diseases.