Please use this identifier to cite or link to this item: https://er.knutd.edu.ua/handle/123456789/25246
Title: Triggering of major brain disorders by protons and ATP: the role of ASICs and P2X receptors
Other Titles: Активація основних розладів мозку протонами та АТФ: роль ASIC і P2X рецепторів
Authors: Cherninskyi, Andrii
Storozhuk, Maksim
Maximyuk, Oleksandr
Kulyk, Vyacheslav
Krishtal, Oleg
Keywords: ASICs
P2X receptors
stroke
chronic pain
epilepsy
neurodegenerative
psychiatric diseases
Р2Х рецептори
інсульт
хронічний біль
епілепсія
нейродегенеративний
психіатричні захворювання
рецептори
антагоністи
біль
Issue Date: 29-Nov-2022
Citation: Triggering of major brain disorders by protons and ATP: the role of ASICs and P2X receptors / A. Cherninskyi, M. Storozhuk, O. Maximyuk, V. Kulyk, O. Krishtal // Neuroscience Bulletin. – May, 2023. – Volume 39, Issue 5. – Р. 845-862. – Режим доступу: https://link.springer.com/article/10.1007/s12264-022-00986-8
Source: Neuroscience Bulletin
Abstract: Adenosine triphosphate (ATP) is well-known as a universal source of energy in living cells. Less known is that this molecule has a variety of important signaling functions: it activates a variety of specifc metabotropic (P2Y) and ionotropic (P2X) receptors in neuronal and non-neuronal cell membranes. So, a wide variety of signaling functions well fts the ubiquitous presence of ATP in the tissues. Even more ubiquitous are protons. Apart from the unspecifc interaction of protons with any protein, many physiological processes are afected by protons acting on specifc ionotropic receptors–acid-sensing ion channels (ASICs). Both protons (acidifcation) and ATP are locally elevated in various pathological states. Using these fundamentally important molecules as agonists, ASICs and P2X receptors signal a variety of major brain pathologies. Here we briefy outline the physiological roles of ASICs and P2X receptors, focusing on the brain pathologies involving these receptors.
DOI: 10.1007/s12264-022-00986-8
URI: https://er.knutd.edu.ua/handle/123456789/25246
Faculty: Факультет хімічних та біофармацевтичних технологій
Department: Кафедра промислової фармації
ISSN: 1673-7067
Appears in Collections:Наукові публікації (статті)
Кафедра промислової фармації (ПФ)

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