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Title: | Triggering of major brain disorders by protons and ATP: the role of ASICs and P2X receptors |
Other Titles: | Активація основних розладів мозку протонами та АТФ: роль ASIC і P2X рецепторів |
Authors: | Cherninskyi, Andrii Storozhuk, Maksim Maximyuk, Oleksandr Kulyk, Vyacheslav Krishtal, Oleg |
Keywords: | ASICs P2X receptors stroke chronic pain epilepsy neurodegenerative psychiatric diseases Р2Х рецептори інсульт хронічний біль епілепсія нейродегенеративний психіатричні захворювання рецептори антагоністи біль |
Issue Date: | 29-Nov-2022 |
Citation: | Triggering of major brain disorders by protons and ATP: the role of ASICs and P2X receptors / A. Cherninskyi, M. Storozhuk, O. Maximyuk, V. Kulyk, O. Krishtal // Neuroscience Bulletin. – May, 2023. – Volume 39, Issue 5. – Р. 845-862. – Режим доступу: https://link.springer.com/article/10.1007/s12264-022-00986-8 |
Source: | Neuroscience Bulletin |
Abstract: | Adenosine triphosphate (ATP) is well-known as a universal source of energy in living cells. Less known is that this molecule has a variety of important signaling functions: it activates a variety of specifc metabotropic (P2Y) and ionotropic (P2X) receptors in neuronal and non-neuronal cell membranes. So, a wide variety of signaling functions well fts the ubiquitous presence of ATP in the tissues. Even more ubiquitous are protons. Apart from the unspecifc interaction of protons with any protein, many physiological processes are afected by protons acting on specifc ionotropic receptors–acid-sensing ion channels (ASICs). Both protons (acidifcation) and ATP are locally elevated in various pathological states. Using these fundamentally important molecules as agonists, ASICs and P2X receptors signal a variety of major brain pathologies. Here we briefy outline the physiological roles of ASICs and P2X receptors, focusing on the brain pathologies involving these receptors. |
DOI: | 10.1007/s12264-022-00986-8 |
URI: | https://er.knutd.edu.ua/handle/123456789/25246 |
Faculty: | Факультет хімічних та біофармацевтичних технологій |
Department: | Кафедра промислової фармації |
ISSN: | 1673-7067 |
Appears in Collections: | Наукові публікації (статті) Кафедра промислової фармації (ПФ) |
Files in This Item:
File | Description | Size | Format | |
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стаття-2022.pdf | 1,17 MB | Adobe PDF | View/Open |
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